Meta-Analysis Of The Relationship Between Particulate Matter (PM10 And PM2.5) And Asthma Hospital Admissions In Children

Objectives To systematically review and assess the relationship between particulate matter (PM10 and PM2.5) and children's hospital admissions for asthma, using both time-series and case-crossover analyses.Method The PubMed, Ebsco, Ovid and four Chinese periodical databases were screened for studies related to short-term effects of particulate matter on pediatric asthma hospital admissions published from 1 January 1990 to 31 December 2013. Relative risk (RR) or odds ratio (OR) and 95% confidence intervals of asthma hospital admissions per 10 ug/m3 increase of daily particulate matter were obtained from each study. RevMan 5.2.11 was used to test the heterogeneity of the results among the different studies and amalgamat the effect size by fixed or random effect model.Result Sixteen studies-on PM10 and 10 studies on PM2.5 were selected finally for meta-analysis. As the concentration of PM10 increased per 10?g/m3, the children's hospital admissions for asthma increased by 1.75%; for PM2.5, a 3.45% increase for asthma hospital admissions as the concentration increased per 10?g/m3. By subgroup analysis based on study design, the effect size on both PM10 and PM2.5 of case-crossover study's results were higher than time-series analysis. Conclusion The short-term increase of the concentration of PM10 and PM2.5 may led to the increase of Children's hospital admissions for asthma, and PM2.5 will present a higher risk contribution.