Application Of ~1H-MRS In Full-term Neonatal Hypoxic-ischemic Encephalopathy And Its Correlation With NBNA Scoring

Objective Analysis of full-term neonatal hydrogen proton magnetic resonance spectroscopy(~1H-MRS) brain metabolite changes, and to assess their full-term neonatal with hypoxic-ischemic encephalopathy(HIE) in the clinical application value. To investigate the correlation between ~1H-MRS and NBNA scoring of full-term neonates with hypoxic-ischemic encephalopathy(HIE).Methods Totally 101 neonates with HIE were enrolled, among whom, 29 was <72 h,33 was 4-7 days and 39 was 8-14 days. In addition, 37 healthy neonates at the same period were enrolled as normal control. All the neonates underwent routine MR scanning, according which HIE was graded, and ~1H-MRS examinations. The N-acetylaspartate,(NAA)/choline(Cho), NAA/creatine(Cr) and Cho/Cr in neonates of different grade HIE and healthy neonates were compared. Neonatal behavioral neurological assessment(NBNA) wasconducted on HIE neonates and compared between HIE neonates of different grade. The correlation between~1H-MRS and NBNA score of full-term neonates with HIE were analyzed.Result NAA/Cho and NAA/Cr ratios of the basal ganglia and NAA/Cho ratios of the frontal lobe in morderate and serious HIE neonates of different days of age were all lower than those in healthy neonates of corresponding days of age(all P < 0.05). In neonates of different days of age, NBNA score of serious HIE was lower than that of moderate HIE.NAA/Cho and NAA/Cr of the basal ganglia and NAA/Cho of the frontal lobe were positively correlated with NBNA score in HIE neonates(r=0.238, 0.221, 0.202, all P<0.05).Conclusion ~1H-MRS is correlated with NBNA score in HIE neonates, which is helpful to detect HIE in full-term neonates and evaluate the extent of brain injury.