Mathematical Model Of Gas Plasma Applied To Wound Healing

In recent years, with the emergence of various cold plasma sources and experimental study of low temperature plasma applied to wound healing, plasma is widely used in clinical treatment. Compared to the traditional chemical reagent treatment, plasma treatment has a smaller skin irritation, less suffering, shorter recovery time and more convenient usage. Given the widely application prospect of plasma in biological medicine, this article established a mathematical model of gas plasma applied to chronic wounds, which is based on biochemistry, to simulate the dynamic process of wound healing. It also had a preliminary study on the mechanism of plasma treatment to the wound healing.This paper selected seven representative species(oxygen, chemical enticement, capillary, blood vessels, extracellular matrix, inflammatory cells, nitric oxide) involved in the process of wound healing as characteristic elements. Through analyzing the relationship between different characteristic elements, a corresponding diffusion reaction equation is established to simulate the epithelial tissue wound healing process. Considering the antiseptic effect of the reactive oxygen species(ROS) and the nitric oxide increasing effect of the reactive nitrogen particles(RNS) to promote the wound healing, this article set up input models of plasma effect including ROS and RNS effects respectively through experiment inductive method, and then put the plasma effect model into the wound healing model to establish a simulation model of plasma applied to the wound healing. By solving the model, the temporal and spatial variation of the characteristic elements in the process of wound healing can be obtained, and therefore the prediction of each stage of wound healing is realized. Based on this model, the conclusions were drew as such: the RNS effect has much less contribution on wound healing than the ROS effect does; though increasing the frequency of plasma treatment can accelerate wound healing process, it tends to a limit value finally. As a development, this paper also provided curative effect of some special types of wound. In the end, this paper provided the application range of the mathematical model and put forward the improvement approach to the simulation.