Retrospective Analysis Of Pulmonary Function In Interstitial Lung Disease

Objective:Parameters of pulmonary function combined with four aspects(smoking history, different imaging performance, blood gas analysis) of interstitial pulmonary disease are studied, thus offering help for diagnosis and treatment of interstitial pulmonary disease.Methods:Retrospective analysis of 61 definite clinical data of interstitial pulmonary disease of our hospital from Jan,2014 to Oct.2014 is done, including clinical symptoms, physical sign, pulmonary function, blood gas analysis, HRCT performance of lung areas and etc. Patients are divided accordingly, ?2 groups based on smoking history, smoking over 10 years and more than 15 daily is smoking group, no smoking history patients are non-smoking group,?collecting high resolution CT of patients, according terming of high resolution CT proposed by Flei scher association, five groups are divided based on imaging performance:(1) Bronchial enlargement of blood vessel bundle group?(2) pleura thickening group?(3) ground-glass opacity group?(4) interlobular septal thickening group?(5) honeycomb group, ?collecting results of blood oxygen from blood gas analysis, patients are normal, light moderate heavy based on hyoxemia. ?collecting data of improved 57 patients, glucocorticoid-treatment group and non-glucocorticoid-treatment group are divided whether patients take glucocorticoid or not. Make comparison of patients parameters of FEV?FEV1?R5?FEV1/FVC?DLCO/VA?DLCO.Results:Patients of interstitial pulmonary disease are 61,26 men,35 women, age scope27-83, averge age 58.79±9.92. (1) among 61 patients, smoking group 25, non smoking group.31. Parameters FVC?FEV1?R5?FEV1/FVC?DLCO/VA?DLCO of pulmonary function show no statistics difference.(2)CT abnormal performance of 61 patients:ground-glass opacity group 42, accounts for 68.85%; interlobular septal thickening group 21,34.42%; honeycomb group 20,32.78%; pleura thickening group 8,13.11%; Bronchial enlargement of blood vessel bundle group 15,24.59%. parts of the cases are one or more than one performance or coexist. Parameters FVC? FEV1?R5?FEV1/FVC?DLCO/VA?DLCO of pulmonary function are pairwise compared, value P is over 0.05, no statistics difference.(3) results of blood gas analysis of 61 patients, normal 16, accounts for 26.22%; hyoxemia patients 45, light 32, 52.45%; moderate 11,18.03%; heavy 2,3.27%?In hyoxemia group, only in R5 group, results of heavy hyoxemia patients show difference from normal, light, moderate group. Heavy and normal groups P=0.01<0.05, difference in statistics. Heavy and light groups P=0. 01<0.05, difference in statistics. Heavy and moderate groups P=0.03<0.05, difference in statistics. Parameters FVC?F EV1?R5?FEV1/FVC?DLCO/VA?DLCO of pulmonary function are pairwise compared, value P is over 0.05, no statistics difference.(4)61 Patients of interstitial pulmonary disease, non-glucocorticoid-treatment improved patients 29, accout for 47.54%; glucocorticoid-treatment patients 32,52.46%; glucocorticoid-treatment improved patients 28,87.5%, glucocorticoid-treatment with no improvement (no obvious relief, CT focus show no absorption or new-onset) 4,12.5%? Group DLCO P=0.048<0.05, DLCO shows clear difference between glucocorticoid-treatment improved patients and non-glucocorticoid-treatment patients, Parameters FVC?FEV1? R5?FEV1/FVC?DLco/VA?DLco of pulmonary function are pairwise compared, value P is over 0.05, no statistics difference.Conclusion:(1)Resistance of air passage viscosity in Heavy hyoxemia patients is higher than other hyoxemia groups.(2) Patients with worse DLCO of interstitial pulmonary disease should consider taking glucocorticoid-treatment combined with clinical performance and related complementary examination.