Relationship Between Homocysteine Levels And Urinary Albumin/creatinine Ratio In Type 2 Diabetes Patients

Objective:The aim of the study was evaluated the relationship of homocysteine levels and urinary albumin/creatinine ratio in Patients with type 2 diabetes mellitus,by means of measured homocysteine levels and microalbuminuria/creatinine ratio, conducted between the two correlation analysis and linear regression analysis.it explore the independent risk factors for type 2 diabetes patients with diabetic nephropathy by logistic regression analysis. Methods:This study is a retrospective cross-sectional study enrolled patients Fifth Affiliated Hospital of Xinjiang Medical University, Department of Endocrinology,106 cases for case group and the control group of 100 healthy outpatient in physical examination are the object to collect clinical data, including sex, age, height, weight, history of hypertension, blood pressure on admission, triglycerides, total cholesterol, lipoproteins, smoking history, blood glucose control, drug use, urine albumin and creatinine in urine, the patients were divided into non-diabetic nephropathy group with ACR, early diabetic nephropathy and clinical diabetic nephropathy. the correlation was analyzed between the groups homocysteine levels change with diabetic nephropathy.spearsman correlation analysis and multiple linear regression was used to clear relationship between type 2 diabetes homocysteine levels and diabetic nephropathy. Results:1. Compared with the control group, the levels of homocysteine, ACR levels were higher in diabets(P<0.05); 2.Hcy and ACR have dependablity (P<0.05).3. Linear regression analysis showed that elevated homocysteine is an independent predictors for elevated ACR (P<0.05).4. Multivariate logistic regression analysis showed that elevated homocysteine is an independent predictor of type 2 diabetes developed into diabetic nephropathy. Conclusion:homocysteine levels positively correlated with elevated ACR. Elevated homocysteine is an independent predictor of type 2 diabetes developed into diabetic nephropathy. on the early diagnosis of diabetic nephropathy, Detection of homocysteine has clinical significance of treatment and prognosis.