The Correlation Between The Levels Of CYFRA21-1,CEA And The Prognosis In Non-small Celllung Cancer:a Systematic Evaluation

Objective:To asses the value of serm cytokeratin 19 fragment(CYFRA21-1) and careinoma embryonic antigen (CEA) in the prognosis of non-small cell lung cancer (NSCLC).Methods:PubMed、Medline、Ovid、Ebsco、Web of Sience、Cochrance library EMbase、CBM and CNKI were searched for collecting studies on the correlation between the levels of CYFRA21-1, CEA and the prognosis in non-small cell lung cancer,and relevant articles were also retrieved from inception to April,2014.Two reviewers independently screened the literature,extracted and data, and ealuated the quality. Then the meta-analysis was performed by using Revman5.1 software, and the publication bias of literature was evaluated by means of Begg’s funnel plot. Results:Finally 12 cohort studies involving 2510 patients were included. The meta-analysis showed that, patients with high level of CYFRA21-1 had poor overall surivival(HR=1.68,95%CI 1.51,1-88, P<0.001).Patients with high level of CEA had poor overall surivival also(HR =1.23,95%CI 1.10,1.36, P=0.001).The results of subgroup analyses showed that there was no statistically significant difference of gender, pathological type,clinical staging in patients with non-small cell lung cancer with expression rate of CYFRA21-1 and CEA. The jointed detection was had a higher prognostic value and a longer lifetime.The disease-free survival midterm digits of CEA≥5 ng/ml and CYFRA21-1<3.3 ng/ml in NSCLC patients was 15.0 months,95%CI:(5.7,24.3),P<0.05,the difference was statistically significant.Conclusion:detection of serum CYFRA21-1 alone for non-small cell lung cancer prognosis evaluation efficiency separate detection of CEA, the joint detection could be more reliable.Conclusion:Separated detection of serum CYFRA21-1 on non-small cell lung cancer prognosis evaluation effectiveness is better than CEA, the joint detection could be more reliable.