Synthesis Process Of Apixaban

This article mainly introduced the synthetic route of the technology of apixaban API of exploration and optimization, and the related impurities has made the preliminary research and synthesis.With thrombotic disease threat to human health is more and more big, the demand of thrombotic disease drugs more and more is also high.As a new generation of oral anticoagulants Xa factor, the Apixaban increases more choice for the prevention and treatment of thrombotic diseases.Now in include the United States, the European Union, China, many countries and regions, mainly used for clinical patients with hip or knee replacement surgery of thrombosis prevention, and prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.Thus can develop a industrialized production of synthetic route is of great significance.This paper has reported the apixaban synthetic route to integrate research, sorting out a possible route is industrialized production, and then on this basis, through the groping and optimize the experimental conditions, to develop a low cost and green environmental protection, suitable for the process route of industrialization operation, at the same time carries on the preliminary research of relevant impurities, provide some data support for the declaration of the drug.