| BackgroundStroke is a serious threat to global health, causes serious heavy burden of disease for the high recurrence, high mortality and high disability. After the part of clinical intervention taken the situation has slowed, however, the global incidence of stroke is still high.ObjectiveUsing the global burden of disease and the published studies of high quality that reported stroke epidemic situation to make the appropriate specific model and estimation method. Application of data from studies worldwide, it is the first time to provide the first comparison of age-specific and gender-specific incidence of stroke between high income countries (HIC) and low and middle income countries (LMIC), and the incidence of stroke is drawled worldwide which is also important to provide the basis for understanding distribution of stroke worldwide and setting up the strategy of preventing and controlling stroke in regions.MethodSystematic electronic searched of MEDLINE, EMBASE and hand back from 1990 January to 2013 June were performed to identify published stroke population-based studies. We used epidemiological modeling to define age-specific and Sex-specific incidence rates and 95% CI in HIC and in LMIC and together with UN population sizes for 2010 to estimate the global prevalence of stroke.ResultsThe incidence of stroke was different around the world. Age-adjusted incidence of stroke in Netherlands and Bulgaria was relatively higher,620 and 551 per 10 million respectively. The age-adjusted incidence of stroke in Belarus, Ukraine, and Iran were 285,256, and 226 per 10 million respectively. The age-adjusted incidences of stroke in French, Libya were relatively lower,64 and 74 per 10 million respectively.The incidence of stroke increased across all ages both in HIC and LMIC. In HIC the incidence of stroke did not differ significantly between men and women with incidence higher in men than in women from 50-54 years. However, In LMIC the incidence rate at all ages was consistently higher in men than women.Comparing HIC with LMIC, the incidence of men with stroke was higher in LMIC at all ages, as well as women. In HIC, the incidence at age 50-54 years was 73.39 per 10 million (67.06-80.31) in men and 72.63 per 10 million (66.73-79.06) in women, and at age more than 90 years, it was 3917.74 per 10 million (3334.55-4598.07) in men and 2735.23 per 10 million (2349.28-3182.52) in women. Incidence in men and women was higher in LMIC than in HIC (110.72 per 10 million (93.21-131.52), 93.33 (79.71-109.29) respectively at 50-54 years and 4749.91 per 10 million (3355.43-6683.85),3954.83 per 10 million (2896.41-5378.61) respectively at 90+ years.There were 6476 627 stroke new cases in 2010:1903 509 stroke new cases in HIC,847903 for male,1055 606 for female; 4 709 119 stroke new cases in LMIC,2 302 951 for male,2 406 168 for female. And the new cases in LMIC was 70.61% in total cases.Conclusion1. There is lots of difference for the incidence of stroke around the world.2. The incidence of stroke increased across all ages both in HIC and LMIC, the major burden of stroke was seen in participants between 60 and 80 years of age.3. Comparing HIC with LMIC, the incidence of men with stroke was higher in LMICs at all ages in men, as well as women.4. Globally, more than 6 million people with first stroke events occurring in 2010, and more than two-thirds of strokes occurred in LMIC. |
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