Synthesis And Antimicrobial Activity Of 2H-chromene’s Analogues

2H-chromene derivatives can be insecticidal and anti-plant fungal diseases which contain the inhibition or lethal effect.It has been widely attention in agricultural production.The purpose of this paper is that finds the structure activity relationships of 2H-chromene structure and the antibacterial activity,which has the reference to the synthesis of 2H-chromene in the field of pesticide.In this paper,the 2H-chromene structure as the core,followed multi-step synthesis of the target compounds.A total of 11 compounds were synthesized,and their biological activity of 14 strains of fungi were tested.The results were as follows:1.Synthesis:The synthesis based on the new series reaction mechanism of spirooliganones A and B.8-(3-methyl-2-butenyl)-2H-chromene(2a)was synthesized,and-methyl(2b)at C-3,and-methyl(2c),-phenyl(2d),-dimethyl(2e)at C-2,and-methyl(2k),-methoxy(21),-fluoro(2m)at C-6,2,2-dimethyl-8-(3-methyl-2-butenyl)-2H-chromene-6-carboxylic acid(7),8-(3’,3’-dimethylallyl)-hexaene(8),anthyllisone(9),all compounds are based on the structure of 2a.The yields of all compounds were higher than 70%.2.Fungal activity:This paper used the mycelium growth rate method.The results of the experiment combined with the significance analysis showed that the antibacterial activity of 2c compound and natural product 7 was significantly better than that of Carbendazim and Azoxystrobin-DMSO at 100μg/mL concentration.3.Structure-activity relationship:The electronegativity and the carbon chain length of substitution at C-6 position,with the type of substitution at C-2 position affect the antibacterial activity of 2H-chromene derivatives together.