| Recent years,with the increasing demand for drugs,drug abuse has become one of the crucial problems in current society,so building a simple,fast and accurate drug detection method to achieve the real-time monitoring to pharmaceutical preparations and residual drugs of the environment is very important.Electrochemical sensing technology is often used in the field of electrochemical analysis because of its simple operation,low cost,fast detection and high sensitivity.In this paper,WO3-g-C3N4/GCE electrochemical sensor was fabricated by using WO3-g-C3N4 composite nanometer material to modify the electrode.The performance of the sensor was investigated and used to detect the actual drug.The main research contents are as follows:Firstly,tungstate melamine single source precursor was prepared by using melamine and ammonium tungstate as raw materials,then WO3-g-C3N4 composite nanomaterials were synthesized by thermal polymerization method,then characterized by TEM,EDS,XRD and FTIR.The results show that the material retains the structural characteristics of pure phase g-C3N4 and successfully introduces the tungsten source,forming the heterojunction structure of WO3 and g-C3N4.Secondly,the modified WO3-g-C3N4 composite nanometer material was modified to the surface of the treated glassy carbon electrode to construct a modified electrochemical sensor for the detection of paracetamol.The results show that the sensor has a good electrochemical response to the acetaminophen with the linear range from 0.10 to1.0×102μM and the detection limit is 3.3×10-2μM.Also,the anti-interference ability and stability of the sensor are evaluated and the sensor is applied to the actual sample detection.Thirdly,the WO3-g-C3N4/GCE electrochemical sensor was prepared by modifying the prepared WO3-g-C3N4 composite nanometer material onto the surface of the treatedglassy carbon electrode.The sensor was applied to the detection of ofloxacin in the concentration range from 1.0 to 60μM,with the corresponding detection limit is 0.35μM.The sensor has good stability and strong anti-interference ability.Fourthly,The ultrathin g-C3N4 nanosheets were obtained by ultrasonic stripping of g-C3N4 and used for electrode modification to prepare electrochemical sensors for the detection of tryptophan.The sensor was applied to the detection of tryptophan in the concentration range from 0.1 to 110μM,with the corresponding detection limit is 0.024μM.In this paper,WO3-g-C3N4 composite nanomaterials were used as modifying materials to construct electrochemical sensors for the detection of drugs.The results show that the WO3-g-C3N4/Nafion/GCE sensor has a high sensitivity of electrochemical response for some drugs. |
