Transition-metals-catalyzed C-N,C-X (Halogen) And C-C Bonds Formation

Transition-metal-catalyzed carbon-nitrogen,carbon-halogen and carbon-carbon bonds formation have been a topic of great interesting in the field of organic chemistry.It is the most simple,efficient and economical way to achieve these new bonds by C-H bond activation,which can not only improve the efficiency of reactions,but also has high selectivity.In this thesis,we focus on the reactions which using transition metal as catalyst to build the carbon-nitrogen,carbon-halogen and carbon-carbon bonds with high efficiency and selectivity.This paper is mainly composed of following three parts:In part one,we investigated and summarized the application of benzoxazine in pesticide and medicine fields,and the synthetic methods to build benzoxazine in recent years.We can synthesize a series of benzoxazine derivatives efficiently by C-H bond activation,which provides a novel approach for the synthesis of benzoxazine scaffold.In part two,we also investigated and summarized the application of the indoline derivatives and their functionalization,and then,we studied ruthenium-catalyzed the C-5bromination in indoline selectively.In part three,the transition-metal-catalyzed transformation of alkenylation was summarized,and the reaction of 1,2-Diphenylethylenediamine as a alkenylation source catalyzed by ruthenium compounds was studied.Raw materials and products were identified by ¹H NMR,¹³C NMR,and a possible reaction mechanism was aslo proposed.