Directing Group Assisted C-C Bonds Formation Via Ruthenium Catalyst

C-H bond functionalization has become a powerful tool in organic synthesis in recent years,through the transition metal insert to activate the C-H bond,found the role of transition metal catalyst,and advanced discoveries.Although the idea of using the C-H bond as the starting point for chemical synthesis has become popular,the activation for stronger C-H bonds and control of site selectivity are two major challenges in C-H activation studies.In this paper,the C-H functionalization catalyzed by transition metal ruthenium was studied.The main contents of this paper are divided into the following three partsIn the first part,the types of directing groups,and the reactions involving different transition metals catalysts in recent years,and the introduce of C-C bonds formation via various C-H functional reactions catalyzed by ruthenium catalysts have been discussed.As well as the progress of organic fluorides,and the reactions were reviewed.In the second part,ruthenium-catalyzed selective C-H oxidative olefination with indolines directed by pivaloyl amide has been developed.The range of olefins was the broadest reported for this kind of C-H alkenylation reaction.For example,acrylates,acrylonitrile,propene,allyl alcohol,?,?-unsaturated ketones,?,?-unsaturated sulfoxide,and?,?-unsaturated phosphonate were all tolerated in this C-H transformation.In the third part,a ruthenium-catalyzed remote C-H difluoroalkylation of8-aminoquinoline scaffolds on the C5 position is described.The reaction has broad substrate scope,highly regioselectivity,operational simplicity,and high efficiency and provides a facile and useful access to the corresponding C5-functional difluoromethylated 8-aminoquinolines is good to excellent yields.All the structure of starting materials and products by ¹H NMR,¹³C NMR,partially ¹⁹FNMR and HRMS analysis.