Study On The Synthesis Of 1,2,4-Trisubstituted Imidazole Compounds Catalyzed By Copper

Imidazole skeleton and its derivatives,a class of important nitrogen heterocyclic compounds,were widely used in the biological,chemical,pharmaceutical and other fields.The synthesis of imidazole compounds has attracted a lot of interests from organic chemists.For a long time,the construction of C-N bond catalyzed by transition metal was continuously founded,which provides a new way of the synthesis of various nitrogen heterocyclic skeleton.Among them,cheap and low toxicity copper salts has been widely used in a series of heterocyclic construction.In chapter one of this paper,the construction of C-N bonds catalyzed by copper salts was reviewed.The synthesis of multi-substituted imidazoles and aryl imidazole derivatives were summarized from different reaction reagents and catalytic conditions.In chapter two,the synthesis of multi-substituted imidazoles was mainly studied.The substituted imidazoles was obtained by using aryl enamide and benzylamine catalyzed by CuBr and I2,at 60 °C for 8 hours in 1,4-dioxane with a C-H bond activation,C-N bond construction and cyclization progress.The reaction does not require a valuable catalyst and exhibits good regioselectivity,showes very good functional group suitability and good target product yields.The reaction would have a good application prospects in the field of medicine,agriculture and new materials.