Study On Metal-organic Frameworks Used As Chiral Additives In Polymer-membranes

Chirality is a universal phenomenon in nature.Some enantiomers show a unique biological activity.The production of a pure enantiomer is essential to medication safety.The membrane separation outperforms other techniques for the resolution of racemic mixtures because of its low cost,energy saving potential,continuous operation and easy scale-up.Homochiral MOF-polymer-membranes possess high enantioselectivity because of its high porosity and low mass transfer resistance.This dissertation focused on MOF-polymer-membrane to separate DL-hydroxyphenylglycine and DL-Methionine.The main works are summarized as follows:1)[Zn₂Camph₂（dabco）]·DMF·H₂O,[Zn₂Camph₂bpe]·5DMF·H₂O and[Mg（L-tart）（H₂O）?1.5H₂ O were synthesized as stationary phase for HPLC,whichwere used to separate DL-hydroxyphenylglycine and DL-Methionine.The experimental results showed that Zn（dabco）-MOF columns,Zn（bpe）-MOF columns and Mg（L-tart）-MOF columns possessed good separation ability for DL-hydroxyphenylglycine or DL-methionine.2)With [Zn₂Camph₂（dabco）]·DMF·H₂O as the chiral additives to prepare cellulose acetate membranes,the membrane of Zn（dabco）-MOF could separate the DL-hydroxyphenylglycine by concentration,pressure differential mode.Some effect of operation parameters were studied.3)Using [Zn₂Camph₂（dabco）]·DMF·H₂O as the chiral additives to prepare cellulose membranes,the membrane of Zn（bpe）-MOF could also separate the DL-hydroxyphenylglycine by concentration,pressure differential mode.4)The membrane of Mg（L-tart）-MOF could be prepared by mixed[Mg（L-tart）（H₂O）]?1.5H₂ O and cellulose acetate.Under the concentration orpressure differential,the optical resolution of the DL-methionine has been arrived.However,a low permeability in the mixed film may be observed.