The Study Of Poly(styrene-co-maleic Anhydride) Grafted With Borneol Capable Of Resisting Fungal Contamination

Microbial can colonize on the surface of medical devices and eventually leads to formation and establishment of proliferating biofilms causing threat to human health. What's more, the use of antibiotic has caused the appearance of the “super bug". Nowadays, antimicrobial materials has great needs in medical devices, water purification system,food packaging and storage, textile and so on. Antimicrobial agents are employed, but they suffer from many disadvantages including toxicity,short-term capability and drug resistance. To address this issue, it is a good way to introduce antimicrobial agents into polymer molecules.Antimicrobial polymers has many advantages, such as reducing the residual toxicity and minimizing the environmental problems, enhancing the efficacy and prolonging the lifetime of the antimicrobial agents. Poly(styrene-co-maleic anhydride) (PSMA) is a largely applied thermoplastic polymer with low price and good quality. However, itself is not an antimicrobial polymer. PSMA can be a promising candidate for designing antifungal polymer, since maleic anhydride (MA) can be easily reaction with the functional molecules containing hydroxy and amino group.Bomeol is a chiral bicyclic monoterpene containing hydroxyl with good antimicrobial property, rich source and low price. Herein, Bomeol is grafted for the first time onto the PSMA (PSMA-g-Borneol) via a one-step esterification reaction to obtain long-term antifungal material because of stereochemical effect. PSMA-g-Borneol exhibits good thermal stability and has also remarkable antifungal activity even after 36 times high pressure steam sterilization. Detail of study methods and conclusions as follows:1. PSMA-g-Borneol was prepared via one-step esterification reaction with a yield of 76%.2. PSMA-g-Borneol was characterized by ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FTIR),1H nuclear magnetic resonance ('H NMR), circular dichroism (CD),Water contact angle(WCA), thermogravimetric analysis (TGA),differential scanning calorimetry (DSC). The observations proved the successful grafting of Borneol onto the PSMA with a grafting ratio approximately 60%.3. PSMA-g-Borneol are challenged with Aspergillus niger and Penicillium glaucum. It exhibits an long-term antifungal performance compared with pristine PSMA.4. PSMA-g-Borneol exhibits good thermal stability and has also remarkable antifungal activity even after 36 times high pressure steam sterilization.This strategy provides a simple, efficient and scalble method to prepare PSMA-g-Borneol with long-term antifungal activity. Thus, this material may has great potential applications.