Study On Copper Micro/Nanometer Materials Catalyze Suzuki Cross Coupling Reaction

The Suzuki cross-coupling reaction is one of the most important tools for the construction of carbon-carbon bonds in modern organic synthesis chemistry.The product of reaction is wildly used as precursors for pharmaceuticals,polymers,materials and liquid crystals.As the traditional Suzuki cross-coupling reaction catalyst,the high price and strong toxicity of palladium hinder the applications of the reaction.At the same time,the catalyst always needs a large number of phosphine coordinators which are extremely toxic to the environment.Therefore,developing a cheap,high efficient,low toxic,recyclable catalyst is receiving increasing attention.Compared with palladium,copper is a kind of cheap and low toxic metal.Thus,it is of vital theoretical and practical significance to apply the copper catalysts well in the Suzuki cross-coupling reaction.In this paper,hollow spheres and flower-like copper nanostructures catalyzed Suzuki cross coupling reactions were studied.First of all,we prepared the above two features of nano-copper catalysts.Then we inspected the catalytic performance of catalysts separately,the effect of various factors in this reaction and the recycling condition of catalysts by taking the reaction between phenylboronic acid and iodobenzene as the model.In addition,we made a primary study of the reaction between different substrates.The result indicated that the two kinds of nano-copper catalysts both had good catalytic activity to the Suzuki cross coupling reaction,and the catalytic activity did not show significant decline after being recycled for three times.Under the conditions of 4-iodotoluene 1 mmol?phenylboronic acid 1.5 mmol?hollow copper spheres 0.2 mmol?K2CO3 3 mmol?DMF 5 mL?temperature 110 ??reaction timel2 h,the coupling reaction yield achieved 56.4%.