The Research Of Medical Hydrogel Materials

Hemorrhaging is a leading cause of death after traumatic injury on the battlefield especially in out-of-hospital,emergency conditions.Therefore,searching for a dressing combining injectability,rapid mechanical recovery,physiological stability,and the ability to promote coagulation is imperative.Here we present a series of injectable polyaspartic acid/alginate(PASP/ALG)hydrogels fabricated by self-crosslinking of hydrazide-modified polyaspartic(PAHy)and aldehyde-modified alginate(ALGALD).Both the degree of PAHy modification and the oxidation degree of ALGALD could be adjusted by the amount of activators and sodium periodate,respectively.The effect of the solid content of the hydrogels and oxidation degree of ALGALD on the gelation time,equilibrium swelling,mechanical properties,microscopic morphology,and in vitro degradation of the hydrogels was examined.Moreover,fibroblast growth factor-2(FGF-2)was incorporated into the hydrogels to facilitate wound healing and in vitro release of FGF-2 was examined.Furthermore,ALG combine Ca2+ network were added to this meterials to enhance the mechanical behavior.As a result of optimization experiments,the performance has got an increase of 60%.In addition,Chitosan quaternary ammonium was participated in this setup in order to endue the antibacterial to material.The capability writing above have all examined.