Disulfoxide-palladium-catalyzed Oxidative Allylic C-H Amination

In recent years, the transition metal catalyzed coupling reactions for C-N bond formation, including alkenyl, aryl, allyl and alkyl of C-N bond reactions have been made some progress, and applications in in the total synthesis and Drug Synthesis.Challenging substrates and conditions in homogeneous catalysis usually pose a very stringent demands on the ligands used. In this paper, 12 novel disulfoxide ligands were designed and synthesized, and the best 1-adamantyl-substituted disulfoxide ligand was screened out. The catalyst permits the allylic oxidative C-N coupling reaction to proceed at lower catalyst loading (2 mmol%) while requiring smaller excess of reagents. Additionally, this ligand improves the availability and the yields of the C-N bond coupled substrate,a substrate that permits deprotection under both acidic and basic conditions, is used.