The Studies Of Pd-catalyzed Ortho-C–H Activation/Annulation Reaction Of Aryl Amides Or Imines

Recent years,the transition metal-catalyzed ortho-C–H activation/annulation reaction of directed group has become one of the effective methods to build all kinds of natural products,drug molecules,material molecules and important compounds.By means of coordination interaction of directed group,this type of reaction will first activate the ortho-C–H bond of directed group,thus form a C–C bond,and then inhibit cis-β-H elimination to construct a heterocyclic or cyclic molecule by the reductive elimination of C–C or C–heteroatom bond,avoiding the complicated prefunctionalization of the substrate.This thesis involves two methods to construct dihydroisoquinolinone and indenone molecules via Pd-catalyzed ortho-C–H activation/annulation reaction of directed group,and mainly include two aspects below:1.Demonstrated a novel and effictive method to synthesize N-alkoxy dihydroisoquinolinones via Pd-catalyzed and arylamide-directed intermolecular sp~3 C–H activation/annulation reaction.In the reaction,peroxide played a role of both building block and oxidant.This method is simple,fast and eco-friendly,meanwhile it has high yield and high atomic economy.2.Introduced a method to synthesize indenones via Pd-catalyzed intermolecular sp~2 C–H activation/annulation reaction.With arylimine as a directed group,the reaction underwent two C–H cleavage and two C–C formation,thus obtaining indenones by ring closure.