Visible-light-promoted C–H Arylation By Mergering Palladium Catalysis With Organic Photoredox Catalysis

Coenzymes are very important in the human’s redox reactions,appear in many metabolic reactions of cells.In recent years,more and more researchers concerned about the coenzyme model in the chemical reactions.It is reported that coenzyme models can participate in many chemical reactions.It can replace some of the metal catalyst,such as the use of coenzyme model as a catalyst can activate olefins,reducing α,β-epoxy ketone and α,β-butanone and oxidation of sulfur compounds.In recent years,organic molecules have become more and more concerned with the use of single electron transfer as a photocatalyst to complete catalytic.AcrH2-A(10-ethyl-9,10-dihydroacridine)as a coenzyme model,it has the advantages of low cost,environment-friendly,it can be used as a photocatalyst to complete the single electron transfer process.This paper reports that AcrH2-A as a photocatalyst,interacts with palladium acetate,to form a dual-catalyzed C-H bond activation reaction.AcrH2-A can form aryl radicals of aryl tetrafluoroboric acid under the initiation of blue light.Under the guidance of palladium acetate,acetonitrile can be used to achieve the direct arylation of aromatics and aryl diazonium salts.The use of a dual palladium/organic photoredox catalytic system enables the directed-arylation of arenes with aryldiazonium salts with broad substrate scope at room temperature under mild reaction conditions.This study thus serve as not only an alternative route for the biaryl motifs but also a new example for the application of organic photoredox catalyst.