The Synthesis Of Bisphenol A Magnetic Molecularly Imprinted Polymer Nanospheres And The Research Of Separation And Analysis Performance

In this paper,the research progress and development trend in:Separation and preconcentration of trace bisphenol A(BPA)in environmental samples,magnetic molecular imprinted technique,magnetic surface molecularly imprinted solid phase extraction technology,and research progress and development trend of preparation technology of BPA molecularly imprinted polymers were reviewed.Study on the preparation of BPA magnetic molecularly imprinted polymer(MMIP)was explored and its separation and enrichment performance towards BPA in the environmental water samples was discussed.Magnetic dummy molecularly imprinted polymers(DMMIP)of BPA on the surface of magnetic nanospheres was synthesized as the new sorbent of the solid phase extraction(SPE),and applied to the determination of BPA in plastic bottled beverages.A new method of DMMIP-SPE-high performance liquid chromatography(HPLC)was established to determine the content of BPA in bottled beverages.The surface molecularly imprinted technology combined with sol-gel method were used to synthesize homogeneous,monodisperse and superparamagnetic BPA-Fe3O4@MIPs on the surface of magnetic core by only one step.The morphology,structural properties and stability of the prepared magnetic nanoparticles were characterized by XRD,TEM,SEM,FT-IR and VSM.The effects of the amount of NH3 · H2O,the composition of solvent,and the ratio of functional monomer and crosslinking agent on the morphology of polymer were investigated.Under the optimum conditions,the adsorption properties of Fe3O4@MIP and Fe3O4@NIP in aqueous solution were studied.The results show that this method was not only simple and efficient which avoided the tedious modification process and provided a good method for polymer material productionbut the materials obtained have high adsorption capacity(402.3 mol g-1),fast adsorption rate(30 min),good selectivity and high recycling.DDBP was used as dummy template to synthesize BPA-DMMIPs on the surface of Fe3O4-COOH nanospheres through a one-step sol-gel method.The BPA-DMMIP was characterized by IR,TEM and SEM,and the adsorption properties of the surface imprinted polymers were evaluated,the results showed that BPA-DMIP owned a high adsorption capacity towards BPA(444.6 μmol g-1),and the adsorption equilibrium could be reached in 30 min.In the meanwhile,the material displayed high selectivity and special affinity to BPA.The materials obtained not only avoided the leakage of the template molecule,but also greatly simplified the process of solid phase extraction which laid a foundation for establishing a method to determine and analyze BPA in environmental samplesBased on magnetic molecular imprinting solid phase extraction method,the separation and enrichment of BPA by DMMIP was applied to plastic bottled drinks.The effects of adsorbent mass,solution pH,eluent composition and elution time on the recovery rate of solid phase extraction were studied,and a new method for the determination of trace BPA by DMMIP-SPE-HPLC was established.The results show that under the optimal conditions,it only need 30 s for BPA to be removed from the DMMIP materials.The results showed that under the optimum conditions,the enrichment factors of M-SPE could reach 400 times and the rate of recovery was still higher than 89%,and the recovery rate was still high when the solid phase extraction elution process was repeated 6 times.In addition,the recovery of BPA was determined by the method of standard recovery.The recovery rate was 88.6-99.5%,the lowest detection limit(LOD)was 0.083 ng mL-1,and the relative standard deviation was less than 9.5%.