Synthesis And Applications Of Nanomaterials Functionalized By Ir(Ⅲ) Complexes

Among core-shell nanoparticles materials,silica nanoparticles have attracted extensive interests because of a good chemical inertness,non-toxicity,good biocompatibility and surface modification.In addition,Ir(Ⅲ)complexes have unique photophysical and photochemical properties,therefore,iridium(Ⅲ)complexes embed silica nanomaterials are gradually being used in biological imaging,biological markers,biological chemical sensors and so on.Ru(bpy)32+-encapsulated silica nanoparticles have been extensively studied in the last few decades with relatively few reports of the incorporation of more hydrophobic cyclometalated iridium(III)species into silica.To flurther develop of the applications of hydrophobic Ir(III)complexes,the main contents of this work are as follows:In the first chapter,the characteristics of the core-shell nanoparticles materials and their preparation,modification and applications were reviewed.At the same time,the applications of the Ir(III)complexes encapsulated silica nanoparticles in the field of biochemical analysis were introduced.In the second chapter,1,10-phenanthrolin-5-amine covalently grafted to 3-(triethoxysilyl)propyl isocyanate is used as not only the sol-gel precursor but also as the second ligand of the[Ir(C^N)2-m-Cl]2 complex to prepare the Ir(Ⅲ)complexes encapsulated silica nanoparticles.Covalent grafting of the Ir(Ⅲ)complexes to the backbone of silica-based networks via the Si-CH2 bond.In order to find suitable biomedical applications based on d6 transition metal complexes of multifunctional nanoparticles,magnetic Gd ion were modified to the silica shell by means of covalent bond,and then the target recognition molecules folic acid were modified onto the surface of the silica nanoparticles through amido bond reaction.The morphology,luminescence properties,cell toxicity and imaging of the magnetic luminescent nanoparticles were characterized.Experiment results show that the particle size are uniform,and the paramagnetic-dye-doped silica nanoparticles have good water solubility and low toxicity which can be used for magnetic resonance imaging and optical imaging.A thorough characterization of the material confirmed its potential as a very effective bimodel contrast agent.In the third chapter,a new kind of core-shell silicon nanoparticle containing a hydrophobic Ir(Ⅲ)complex by two method has been synthesized.The solubility of iridium(Ⅲ)complexes are greatly improved,the new nanoparticles are uniformly dispersed in the ethanol or water with strong luminescent intensity.Two sensitive methods for determination of cyanide have been developed based on the fact that luminescent intensity of the new nanoparticles in the ethanol or water solution can be enhanced by cyanide.It is noted that two methods are meaningful to expand the application of the insoluble luminescent dye complexes in aqueous solution.