Synthesis Of Porous Magnetic Prussian Blue Nanocomposites

Mesoporous magnetic Prussian Blue（PB）particles are good condidates for theragnostic nanomedicine.However,there are lack of efficient methods for fabrication of such materials.Here,we reported the synthesis of the mesoporous yolk-shell Fe₃O₄@PB particles by one-pot coordination replication and etching.Using Fe₃O₄ spheres as a core,we obtained the mesoporous yolk-shell Fe₃O₄@PB.Time-dependent transmission electron microscopy illustrated that the PB crystals nucleated and grew on the surface of Fe₃O₄ spheres by coordination replication with the help of protons.The extra protons in the reaction medium further disassociated the Fe₃O₄ and PB,leading to mesoporous particles.To promote the application of this method,then using NiFe2O4 as a core,we obtained the porous yolk-shell NiFe2O4@Ni-Fe PBA nanomaterial.Based on the method of synthesis of porous yolk-shell Fe304@PB nanocomposites,we used the mixture solvent of water/DMF and produced core-shell Fe₃O₄@PB hierarchical structure composed of PB nanosheets and core-shell NiFe2O4@Ni-FePBA nanosheets hierarchical structure through coordination replication and controlled etching.The as-prepared porous yolk-shell Fe₃O₄@PB nanocomposites was introduced to the application of multi-function nanomedicine.The mesoporous yolk-shell Fe₃O₄@PB particles showed enhanced efficacy for loading cisplatin.The release of the drug molecules could be facilitated by increasing temperature.Both photo irradiation and alternating magnetic fields could trigger the release of heat from the composite.The obtained materials could delivery cisplatin to kill cancer cell intracellularly.