| Isatin compounds and Benzofuranones have attracted considerable attention of biologists and medical scientists for their excellent biological activity.Wherein the isatin compounds are used as intermediates in organic synthesis,ketones benzofuran compounds also have good antibacterial properties.Thus,synthesis of this series of heterocyclic compounds with simple and effective method is of particular importantance.On the basis of this concept,in this dissertation,we have found a new route to construct indole 2,3-dione and phthalide derivatives.The main content is divided into the following three parts:In chapter 1,we summarized the synthetic methods and the applications in medicinal chemistry and organic synthesis for indole 2,3-dione.Based on our work in study of a-hydroxyacetophenone,also combined retrosynthetic analysis strategy,we suspected to synthesis indole 2,3-diones and benzofuranones from 1-(2-aminophenyl)ethanones and 1-(2-hydroxyphenyl)ethanones in one-pot.Based on this idea,we further attempted to construct a class of novel indole-2,3-diones and 2-hydroxybenzofuran-3(2H)-ones.In chapter 2,based on the important physiological activity of indole 2,3-diketones and its synthesis method literature research,and our work in situ trapping of unstable-ketoaldehyde intermediates strategy to construct diverse compounds through intermolecular reactions,we used aminoacetophenone as substrates to synthesis indole 2,3-diones.Meanwhile,we explored 6 substrates to indole 2,3-dione and two of the target compounds were confirmed by X-ray single crystal diffraction,and we also proposed a possible reaction mechanism.In chapter 3,based on the important physiologically activity of benzofuranones and its synthesis methods literature research,we found that 1-(2-hydroxyphenyl)ethanones could construct 2-hydroxybenzofuran-3(2H)-ones.We explored 7 substrates to 2-hydroxybenzofuran-3(2H)-ones and one of the target compounds was confirmed by X-ray single crystal diffraction. |
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