Direct Triflylation Of Benzylic C-H Bonds With Pyridine As A Directing Group

Recently the trifluoromethanesulfonyl-containing compounds have been widely used in pharmaceuticals,bioactive compounds,catalysts and functional materials.These compounds are receiving more and more attention.Thus,benzyl triflones should be potentially useful.However,the existing synthetic methods suffer from the need of prefuntionalization of benzylic substrates.In this thesis,we are committed to develop an efficient C―H bond trifluoromethanesulfonyl of benzylpyridine and have made some progress.First,various catalytic metal salts,bases,solvents,reagents and directing group were screened to determine the optimal reaction conditions.Then the substrate scope was investigated.Although the applicability of the substrates was uneven,most of the substrates were compatible with the reaction conditions.Finally,we chose 15 repre sentative products with the good yields from 40% to 80%.According to the experiment results,we speculated that the rearrangement of trifluoromethanesulfonyl anion was probably involved in the reaction process.But the exact reaction mechanism is still unclear,the study of which is currently on progress.