| This topic selects montmorillonite(MMT)mineral as raw materials,which prepared the Fe(II)-montmorillonite(Fe(II)-MMT)an d studied the performance of phosphate adsorption,aims to remove excessive phosphate in patients with high blood phosphate,in order to achieve the purpose of the treatment of hyperphosphate.At the same time provides the experimental basis for the medical or pharmaceutical application of montmorillonite mineral,has important theoretical significance and application value.(1)Using montmorillonite as raw material,studied its adsorption performance for ferrous ions.By investigating the initial concentration,time,p H and temperature on the influence of adsorption,the adsorption mechanism of adsorption kinetics,adsorption thermodynamics and adsorption isotherm are discussed.Results showed that the adsorption process fitted with pseudosecond-order and the Langmuir adsorption isotherm model well,and high temperature is beneficial to the adsorption.The materials before and after adsorption have been characterized by X-ray diffraction(XRD),Fourier transform infrared(FT-IR),Surface area and porosity analyzer,Thermogravimetric analysis(TGA),Differential scanning calorimeter(DSC)and Zeta potential distribution.(2)Prepared two kinds of different concentrations(40 mg/L and 80 mg/L)of Fe(II)-montmorillonite.The resulting samples were characterized by X-ray diffraction,Fourier transform infrared,Thermogravimetric analysis,Differential scanning calorimetry and Nitrogen adsorption.In addition,in order to study the removal efficiency of Fe(II)-montmorillonite for phosphate,adsorption experiments at p H2.0,7.6,8.4 were carried out.The results showed that the higher removal rate of phosphate within 40 minutes and the effect of Fe(II)-montmorillonite was better than the raw montmorillonite.(3)Using Fe(II)-montmorillonite as drug delivery system,to study the adsorption performance for phosphate.Phosphate adsorption experiments under different time,p H and initial concentration.Fe(II)-MMT and Fe(II)-MMT-P hybrid were characterized by means of X-ray diffraction(XRD),Raman spectroscopy and Zeta potential measurements.The results showed that phosphate was successfully adsorbed onto surface or into interlayer space of Fe(II)-MMT.The results of experiment with rats suggested that Fe(II)-MMT was able to control the occurrence of hyperphosphatemia by reducing the amount of phosphate.Fe(II)-MMT will become a promising drug delivery system for the treatment of chronic renal failure.Innovation of this paper lies in:1.Using ascorbic acid as antioxidants in adsorption process.2.Prepared Fe(II)-MMT and studied the adsorption performance for phosphate.Fe(II)-MMT had good affinity for phosphate and could be a promising drug delivery system in the treatment of chronic renal failure. |
