| 7-chloro-quinaldic is a white crystalline,stable at room temperature and atmospheric properties,it can be applied to an important new development in recent years,anti-asthma medication-montelukast(montelukast,a selective leukotriene D4 receptor antagonists)synthesis.Given its important pharmaceutical use,7 chloroquinaldine synthesis process is one of hot research.Currently the products are often in 3-chloro-aniline,2-butene aldehyde as the main raw material,nitrobenzene derivative oxidant,be prepared by the classic Skraup Doebner-Miller reaction or response.But at the same time due to the reaction of 5-chloro isomers quinaldic generate such a low yield,while allowing subsequent separation and purification processes cumbersome leading to costly.3-chloro-aniline and aniline hydrobromide by the reaction between chlorine hydrobromide and then with 2-butene in the oxidation of aldehydes nitrotoluene which is directly obtained pyridine hydrobromide corresponding high purity 7-chloroquine,then the target product can be obtained by sodium carbonate and after 7-chloro qUINALDINIC.The process route,mild reaction conditions,less byproduct yield,5-isomer and so,a high purity of 7-chloro-quinaldine.Screened alcohol solvent used in the cyclization reaction process,improved yield,optimizing the process conditions,the reaction at lower temperatures,reducing energy consumption and cost savings. |
