Study On Preparation And Application Of Mesoporous Silica

Mesoporous silica with different morphologies and pore structure was prepared via block copolymer Brij98 and anionic surfactant sodium dodecyl sulfate(SDS)co-surfactant templated synthesis approach with varied salt solution.The resulting mesoporous silica with ordered hexagonal mesostructure and cross-linking wormlike morphologies pores were used as carriers for loaded emodin(EM)as drug model to uncover the in vitro drug releasing kinetics.Scanning electron microscopy(SEM)and Transmission electron microscopy(TEM)showed the morphologies and pore structure of the samples.N2 adsorption-desorption experiments and Fourier transform infrared spectroscopy(FT-IR)measurements demonstrated that EM was adsorbed into the inner pores of the MSs.The relationship between the MSs structural evolution and the surfactant was preliminary discussed,possible mechanisms loading of EM on MS are proposed.It was found that the quantity of the drug loaded mainly depended on the pore size and surface properties of mesoporous silica,while the drug releasing rate was dominantly determined by the length and curvature of the mesopores.mesoporous materials(MVS)and condensation of were synthesized by hydrolysis Vesicle-like silica the silicon source under Brij98 and SDS Co-surfactant template and TMB.Then APTES has been used to modified MVS,the obtianed sample were named as MVS-NH.N2 adsorption–desorption isotherms indicates that are between 100-300 nm,thickness of multilayer structure is about 5 nm,layer spacing is about 4 nm.SAXRD and the vesicular silica possesses The optimum reaction temperature increased from long range framework order and a stable SEM and TEM images show that the size of these vesicles structure,MVS,MVS-NH modified materials Compared to the free enzyme,with 435 cm3g-1 and 598 cm3g-1 of huge specific surface area,respectively.immobilized enzyme shows better adaptability to the environment,and good repeated utilization.40 °C to 50 °C,the highest activity from 520 U/g to 604 U/g,the activity of,keep increase from 49.8 % to 54 % of immobilized PPL of MVS-NH compared with MVS immobilized PPL.Compared to the free enzyme,immobilized the highest activity from 500 U/g to 634 U/g,enzyme shows better adaptability reused keep increase from 52 % to 57 % after 5 times the higher catalytic activity to the environment,the higher catalytic activity,and good repeated utilization.The optimum reaction temperature increased from 40 °C to 50 °C too,the activity of reused after 5 times of immobilized CRL of MVS-0.2 compared with MVS-0.1 immobilized CRL.