Synthesis Of Hydroxy 1,8-Cineole From ?-Pinene Catalyzed By Peroxo-Heteropoly Acid Quaternary Ammonium Salts

The hydroxy derivatives and ester derivatives of 1,8-cineole have better biological activities and applications than 1,8-cineole, but the conventional synthesis method had some disadvantages:its long line of synthetic route, low yields, separation in crude product hard. This paper studied a new method of synthesis of hydroxy 1,8-cineole from ?-pinene. The main content of the page includes the following four aspects:1. Synthesis of hydroxy 1,8-cineole from ?-pinene catalyzed by [?-C5H5N(CH2)11CH3]3PW4O32/H2O2 and its structure was characterized by GC/MS,HR-MS,IR,1H-NMR,13C-NMR.2. A series of peroxo-heteropoly acid quaternary ammonium salts had been synthesized, their structure and character were characterized by IR, UV, ICP, EA. The best process condition of obtained 2,3-dihydroxy-1,8-cineole through the experiments of catalyst, solvent, catalyst dosage, oxidant dosage,reaction temperature and reaction time.3. The scale-up experiment of synthesis 2,3-dihydroxy-1,8-cineole basing on small-scale experiment are studied. separating and purifying the 2, 3-dihydroxy-1,8-cineole by recrystallization,Vacuum distillation and column chromatography has been established.4. Primary discussion for the synthesis mechanism of 2,3-dihydroxy-1,8-cineole in this paper was studied.