Design And Synthesis Of 1,2,3-triazole Derivative Ligands And Its’ Complex With A Study In Their Properties

1,2,3-triazole is an significant pentabasic N heterocycle and is also the bioisostere for amide linkage. It has higher stability than 1,2,4-triazole in metabolic transformation, acid-base environment and redox reaction under high temperature. 1,2,3-triazole is widely used in biochemistry, material chemistry and organic synthesis, etc. In medical chemistry, it contains features such as Beta-lactamase inhibitors, bacteriostat, antineoplastic and anti-HIV. Meanwhile, for its’ abundant coordination electron density of the 1,2,3-triazole ring, it can used to design ligands to catalyze reactions.The reaction between azides and terminal alkyne is called Click reaction and is interestingly studied in medicine, materials and biochemistry., currently. Among all these fields, studies on 1,2,3-triazole catalytic systems are the most important. The commen catalytic system includes Cu(II) + reducing agent, Cu(0) + oxidant, Cu(Ⅰ) + ligands. Desgin a new structure and easy to synthesis ligand that can assist Cu(Ⅰ) catalyze Click reaction efficiently has a great study meaning.In this paper, we designed and synthesized a series of N1, N2-substituted 1,2,3-triazole derivatives ligands which can assist Cu(Ⅰ) catalyze click reaction under mild conditions. Specifically, we study its’ synthesis pathways, structure characterization and catalytic activity. In its’ catalytic systems, we study the usage of the catalysts, solvent, temperature and conversion rate, etc.Meanwhile, we also synthesized a 1,2,3-triazole derivatives ligand, coordinate with Cu(OAc)2 to form a dinuclear Cu complex, we studied its’ fluorescence properties, DNA cleavage activity and its’ cleavage mechanism.