Synthesis And Performance Of Amphiphilic Grafted Polyphosphazenes

Polyphosphazenes have good biocompatibility,biodegradability,low toxicity and relatively stable physical and chemical properties Widely used in controlled drug release,tissue engineering,and received wide attention In the side chain of the poly-chain,the groups of different structures can effectively adjust the hydrolysis,mechanical and surface properties of the polymer,and make it better to be used..Bonded polyethylene glycol and hydrophobic hydrophilic peptides in polyphosphazenes,adjusting the proportion of dear hydrophobic groups,can make the polyphosphazenes with different properties Two dear of polyphosphazene as drug carrier,embedding physical or chemical bonding of drugs,can make the drug targeting and strengthen the proportion of different hydrophobic groups on dear encapsulation and bonded loading can be controlled.In this study,the contents of the two peptides and polyethylene glycol were controlled by the ratio of the five peptides and the polyethylene glycol..The reaction proportion control peptide five and polyethylene glycol two,change of dear polyphosphazene polymers in aqueous solution self-assembly,the stable structure,controllable nano micelles self-assembled after size.Synthesis of different grafting ratio of poly(ethylene glycol)-polyphosphazene peptide amphiphilic polymer OPM-1 and opm-2,was characterized by nuclear magnetic resonance(1H-NMR,31P-NMR),Fourier transform infrared spectroscopy(FT-IR),ultraviolet spectroscopy(UV)method.Using pyrene fluorescence probe method,dynamic light scattering(DLS)self-assembly behavior of two dear carrier polymer in aqueous solution The measured amphiphilic poly phosphazene OPM-1 and the OPM-2 polymer critical micelle concentration(CMC)were 37mg/L 12mg/L;amphiphilic poly phosphazene OPM-1 and OPM-2 polymer hydrodynamic diameter and 10.1nm used for 13.4 nm respectively.