Transtion Metal-catalyzed Carbonylation And Trifluoromethylation Reactions And Hydrogenation Of Carbon Dioxide

Organofluorine compounds have currently attracted widespread interest in the fields of agricultural, medicinal and material sciemces and an extensive variety of synthesis methodologies have been used to target fluorine-containing compounds. Of this group, trifluoromethyl ketones (TFMKs) have been the focus of considerable attention not only because of their outstanding performances in biological activity but also because of their applications in the synthesis of other trifluoromethyl-containing compounds.Thus, the generation of TFMKs has been the focus of considerable attention. Carbon dioxide is the primary carbon source in the atmosphere and provides the basis for all organic matter on earth. Even though CO2 is abundant, cheap, and relatively nontoxic compared to the alternative C1 source carbon monoxide, utilizing carbon dioxide is still a challenge research field due to its thermodynamic stability. This thesis we first especially summarized the development of carbonylation reaction and then simple to learn the hydrogenation of carbon dioxide and bicarbonate to formate. This dissertation is consisted of two parts:In part one, we summarized and analysed the recent research progress on the palladium-catalyzed carbonylation reactions of aryl halides and related compounds. In addition, we reported the palladium-catalyzed carbonylation and trifluoromethylation reaction of aryl iodide. This method provided a new source of substrate and strtegies. At last, we investigated the mechanism.In part two, we described an effective, phosphine-free, air-and moisture-tolerant iron-based catalyst system for the hydrogenation of bicarbonate and carbon dioxide to formate. At last, we investigated the preliminary mechanism.