A Kinetic Model Of Radiation Induced Cell Injury And Its Application

The radiation biophysical model is one of the most important tools to study the radiation biology effect by means of mathematical and physical analysis.It is also one of the important tools to evaluate radiation damage.The traditional radiation biophysical models include the target model,the linear squared model,and the kinetic model.Among them,the kinetic model is often used as a mechanistic model to quantitatively study the radiobiological effects.However,the common kinetic model has a series of problems,such as complex biology that does not consider repair/misrepair/unrepair and so on.Therefore,this study used first-order kinetics and other mathematical methods to establish a kinetic model of radiation-induced cellular DNA damage based on the biological process of radiation damage repair.The study discusses the model under simplified conditions and general conditions respectively,obtains the corresponding analytical solution and the numerical solution,and compares the obtained solutions with the experimental data.In this study,we selected dose-survival data of different cell lines under different dose rates of X-ray radiation.These data are widely accepted and representative.OriginPro 8.0 software was used to fit and analyze the data,and the fitting effect was evaluated by Adj.R2,RSS/dfand ?2/df.The assessment results show that the model has good applicability and is slightly better than the classical model.This study also applied the model to study the biological effects of heavy ion radiation and calculated the relative biological effectiveness and radiation cross-sections of carbon ions under different linear energy transfer.The results showed that the relative biological effectiveness increased with the increase of linear energy transfer,reached the maximum when the linear energy transfer was between 100keV/?m and 300keV/?m,and then decreased with the increase of linear energy transfer.The radiation cross-sections increases with the increase of the linear energy transfer,and when the linear energy transfer is greater than 100keV/?m,the radiation cross-sections is basically no longer changing.The conclusions obtained in this study are consistent with those of previous studies,indicating that the kinetic model of radiation-induced cell injury proposed in this study has a wide range of applicability.