Research Of Sonoporation Of Ultrasound Contrast Agent Near Biological Walls

Ultrasound has the characteristics of short wavelength,strong directivity and controllability,and ultrasonic synergistic microbubbles(ultrasound contrast agent)can produce a series of mechanical and biological effects.With the deep understanding of the characteristics of ultrasound contrast agents and the continuous maturity of their preparation techniques,ultrasound contrast agents in the thrombosis ablation,tumor therapy,and targeted gene drug delivery and other aspects of its huge application prospects.Based on the existing results,the dynamic model of ultrasound contrast agent near biological wall was established by analyzing the interaction between ultrasound contrast agent and biological wall.The dynamic characteristics of ultrasound contrast agent near the biological wall and the sonoporation near the wall were studied.The results show that the closer the ultrasound contrast agent is to the biological wall,the closer the shear stress is.The influence of different acoustic parameters and acoustic reflection coefficients on sonoporation of ultrasound contrast agent was obtained by using the constructed sonoporation probabilistic model.The probability distribution of sonoporation was numericallycalculated.Based on the image method,a dynamic model of the beam contrast agent in the ultrasonic field was established.The acoustic effect of the contrast agent was analyzed by the acoustic reflection effect of the ultrasound contrast agent during the oscillation process of the ultrasound contrast agent.The effects of different biological wall materials and their size on the vibration process of contrast media were investigated.The results show that the narrower spherical region is more narrow and the microbubble vibration is more easily repressed.When the microbubbles are located in the center of the concave spherical surface,the smaller the concave spherical radius,the greater the stress on the wall,the more obvious the sonoporation.The aim of this paper is to explore the interaction between microbubbles and vascular wall by exploring the interaction between microbubbles and biological walls,so as to understand sonoporation of ultrasound contrast agent near biological wall,and to target tumor therapy and drug Transmission and other medical applications to provide theoretical reference.