The Effect Of AMsh Glial Cells On The Olfactory Adaptation Of Caenorhabditis Elegans

Caenorhabditis elegans has a very simple but complete nervous system.Neurons are important members of the nervous system.Glial cells,as another part of the nervous system,have many functions,including support,nutrition,and protection of neurons.The interaction between neurons and glia regulates the living activities of the organism.At present,little is known about the function of glial cells and the interaction mechanism between neurons and glia.The head of the C.elegans has a developed allelopathy system,which can perceive a variety of external stimuli.Olfactory adaptation is an important physiological function of C.elegans,which can protect its cells from excessive stimulation and better cope with the change of olfactory stimulation intensity.In this study,we used molecular genetic technology to specifically mark AMsh glia and ASH neurons.We recorded calcium signal changes of ASH neurons and C.elegans' avoidance behaviors while AMsh glial cells were activated or inhibited.It is preliminarily proved that activation of AMsh glial cells can inhibit the excitability of ASH neurons,and then reduce the susceptibility of C.elegans to disgust smell,thus leading to olfactory adaptation.This study is the first to discover that AMsh glia is involved in olfactory adaptation,and is a good reference for further study of the role of glial cells in the nervous system.