Therapeutic Efficacy And Safety Of Sublingual Immunotherapy In The Treatment Of Adults With Seasonal Allergic Rhinitis:A Meta-analysis

Objective To systematically investigate the efficacy and safety of sublingual immunotherapy(SLIT) in the treatment of adults with seasonal allergic rhinitis(SAR).Methods Literature was retrieved online in CNKI、CBM、VIP、Wanfang data、PubMed、EMBase、Medline、Cochrane Library et al. After screening literature data collection and assessmenting quality,randomized controlled trials relevant to our study were selected independently based on inclusion and exclusion criteria by two researchers.Statistical analyses were conducted by RevMan5.2 software.Results A total of 13 RCTs were enrolled. The meta-analysis revealed that:(1) SLIT provided a significant improvement in aspect of reducing Symptom Scores(SS) and Medication Scores(MS)of adults with SAR(P<0.00001)compared to placebo.(2) SLIT could increase the rate of Adverse Events(AEs)in the treatment of adults with SAR compared to placebo.The frequently reported AEs during clinical trials were oral pruritus,tongue edema, ear pruritus, throat irritation et al.Conclusions Sublingual immunotherapy could improve the symptoms significantly and reduce the SS and MS in the treatment of adults with SAR. And its safety could be well tolerated.