Long Non-Coding RNA-LINC00993 In Triple-Negative Breast Cancer: Expression Analysis And Biological Roles Research

Triple-negative breast cancer(TNBC) represents a collection of malignant breast tumors that are often aggressive and have an increased risk of metastasis and relapse. LncRNAs are involved in almost all human biological processes, both physical and pathological, and that they act as gene regulators at both the transcriptional and post-transcriptional level by binding to DNA, RNA or proteins. Increasing evidence has shown that lncRNAs play important roles in oncogenesis and tumor suppression; however, the roles of lncRNAs in TNBC are poorly understood. Previously, we have identified a dysregulated lncRNA expression profile, and we found that lncRNA-LINC00993 was significantly down-regulated in TNBC tissues and cells. By transfecting TNBC cells with Ad-LINC00993, we also found ectopic expression of LINC00993 cloud resulting in inhibition of cell proliferation and increasing of cell apoptosis rate. Therefore, we believe that LINC00993 is a TNBC associated lncRNA which may play a key role in the development and/or progression of TNBC. We believe our results may provide novel detection markers and potential therapeutic targets of TNBC.