Prostate cancer is common malignant tumor in men, and affects global men’s health seriously and even be life-threatening. Since the advent of widespread PSA screening, the positive detection rate of PCa got significantly improved. Recently, however, several large randomized clinical trials draw different conclusions about whether PSA-based screening cut down on deaths from the disease, and triggered the discussion of the value of PSA screening. over-treatment and over-diagnosis caused by PSA screening are the focus of debate. The improvement of screening strategies, the novel screening tools,active surveillance are the priority research area. |