RNAi Technology Applied To The Preparation Of Molecular Probes For Diagnosis And Treatment Of Ovarian Cancer

Objective: In recent years, RNAi technology is widely used in bio-medical field, and achieved encouraging development in the research of genetic or inherited disease, and the research of anti-cancer therapy. Now, many researchers turned their attention to the application of RNAi in molecular imaging, expect to specifically diagnose tumor or relative disease in the molecular level. This article mainly review the research and development of molecular probes for diagnosis and treatment of ovarian cancer.Methods: The article related to RNA interference and MR molecular probes of ovarian cancer from Pub Med and CNKI database between 1997 and 2014 were retrieved by computer with the key words of “RNA interference, ovarian cancer, molecular probe, molecular imaging”. Finally more than 100 articles were includedResult: Aim at different target of ovarian cancer, the molecular probe with s i RNA could transfect tumor cells effectively and be monitored by MR, which result to promote the apoptosis of tumor cells by the means of effectively transcriptional gene silencing.Conclusion: The technique of RNAi could be used for preparing molecular probes, for making earlier and specific diagnosis, and for targeted gene therapy of malignant tumors. Because of the detailed and excellent spatial resolution, magnetic resonance imaging is the optimal medical image technology at present, the preparation of MR probes with si RNA became the hot area in molecular imaging. With the strengthening of multi-crossed disciplines and multi-fields cooperation, dual-modal or multi-mortal molecular probes will become the research trends in future.