Study On Correlation Between Serum Biochemical Levels And Discharge Outcome In Acute Cerebral Hemorrhage

Background: There remains a proportion of patients with unfavorable outcomes after hemorrhagic stroke. Intracerebral hemorrhage is the most devastating form of stroke,with high case fatality and mortality,and left irreversible neurological impairment.Several factors have been suggested as predicting the outcome.Purpose: In the paper, we test whether,independent of confounding factors,serum biochemical levels on admission are associated with an unfavorable outcome.Methods: we identified all patients who suffered acute primary intracerebral hemorrhage between 2013 and 2015 in the First Affiliated Hospital of Chongqing Medical University.All patients scaled by the modified Rankin Scale(mRS) in the form of a simplified questionnaire at discharge.The modified Rankin Scale was dichotomized to good(mRS 0-3) and poor outcome(mRS 4-6) at discharge.Altogether,300 patients with first-ever primary intracerebral hemorrhage were identified,and complected the routine biochemical indexes included routine blood test,liver function,kidney function,blood coagulation,blood glucose,and blood lipid level in 72 hours. Comparing the high sensitive C reactive protein, globulin, albumin, blood glucose, total cholesterol, low density lipoprotein, high density lipoprotein, hemoglobin, erythrocyte sedimentation rate, fibrinogen between the two group in the good group and the negative group.Result: Compared with the two groups of patients admitted to the hospital, the high sensitive C reactive protein, plasma globulin, blood glucose, fibrinogen level. Baseline measure of High sensitive C reactive protein, plasma globulin, blood glucose, and fibrinogen showed elevated levels in patients with poor outcome compared to good outcome at discharge.The difference was statistically significant.According to the infection,including urinary tract infection, pulmonary infection, sepsis, bedsore infection),we divided the poor group(mRs:4-6) into infection group and non infection group.The two groups of patients admitted to High sensitive C reactive protein, plasma globulin, blood glucose, and fibrinogen without statistical significance.Conclusions: In patients with spontaneous intracranial hemorrhage,the elevated levels of the high sensitivity C reactive protein, plasma globulin, blood glucose and fibrinogen at discharge were associated with discharge adverse outcome.