The Therapeutic Value Of Incretin In Prediabetes

Patients with prediabetes is at high risk of developing the future diabetes and cardiovascular diseases.They have manifested serious insulin resistance, β-cell dysfunction, abnormal incretin secretion or action,etc. And chronic complications have already existed. so there is a urgent need for active early intervention targeted pathophysiological abnormalities,thus preventing diabetes. At present, many studies have indicated that GLP-1 can preserve β-cell function, promote the release of insulin, suppression of glucagon, lose weight, enhance satiety, improve lipid profile,etc. Many clinical studies have demonstrated its effectiveness of delaying the development of diabetes or reverting to normal glucose tolerance.