The Application Of Interferon-Γ Release Assay In Immunocompromised Patients With Pulmonary Tuberculosis

Objective: To investigate the application value of interferon-γ release assay(IGRA) in immunocompromised patients with pulmonary tuberculosis.Methods: 180 cases were chose including immunocompromised patients,pulmonary tuberculosis patients, immunocompromised patients with pulmonary tuberculosis and healthy volunteers to undergo IGRA in order to determine and compare the content of specific interferon-γ(IFN-γ)in plasma.At the same time, the result of immunocompromised patients with pulmonary tuberculosis was compared with tuberculin skin test(TST).P<0.05 was considered statistically significant.Results: 180 cases of the list were tested,included 40 immunocompromised patients(group A),50 pulmonary tuberculosis patients(group B),40 immunocompromised patients with pulmonary tuberculosis patients(group C),and 50 cases in healthy control group(group D).The median of specific IFN-γ contents in the four groups were respectively 0.112 IU/mL、7.835 IU/mL、5.726 IU/mL、0.697 IU/mL. The comparison of differences among the four groups was statistically significant(χ2=74.046,P<0.001).Pairwise comparisons among the four groups, and the differences between group B and group C was no significant, but specific IFN-γ content of the two groups was significantly higher than the other two groups, while the group D was higher than group A, the differences were statistically significant. The positive rate of IGRA was significantly higher than that of TST in group C(χ2=11.314,P=0.001).Conclusion: IGRA diagnosis in the application of immunocompromised patients with pulmonary tuberculosis was less affected by immune status and was more sensitive than TST,which can be used as auxiliary diagnosis.