Analysis Of Bacterial Spectrum And Drug Resistance In 50 Cases Of Severe Acute Pancreatitis Complicated With Infection

Objective:To investigate the bacterial spectrum changes and characteristics of drug resistance of patients with severe acute pancreatitis(SAP) and to guide clinical proper use of antibiotics medicine.Methods:Clinical specimens of 50 patients with SAP were analyzed including sputum, blood, urine, central venous catheter, bile, et al. Bacterial strains were regularly isolated and drug sensitivity test was made by disc diffusion method. Chi-square test was performed for statistical analysis.Results:One hundred and fifty-six bacterial strains were isolated.The number of strains isolated from the sputum, blood, pancreas and abdominal cavity, bile, urine tract, surgical incision, oral secretion is 51、37、24、23、11、8 and 2 respectively. The most common bacterial strains were Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa and Enterococcus faecium, the number of strains was 30, 21, 20 and 14, respectively. The drug resistance rate of Acinetobacter baumannii to imipenem and meropenem was no less than 90%. The drug resistant rate to cefoperazone/sulbactam was lower, but still over 60%. The drug resistance rate of Escherichia coli to penicillins, majority of cephalosporins and quinolones was over 90%. The drug resistant rate of Pseudomonas aeruginosa to partial cephalosporins was high(90%), and the drug resistance rate to imipenem was also up to 65%. The drug resistance rate of Enterococcus faecium to Penicillin G and quinolones was up to 100%. No Enterococcus resistant to tigecycline 、 vancomycin and linezolid was found. The infection rate of patients received invasive operation was higher than that of patients received no invasive operation.Conclusion:The main bacteria of patients with SAP complicated with infection was Gram-negative bacteria, which has high drug resistance. The common locations of infection were respiratory tract, blood, abdominal cavity, biliary system and urinary tract. The infection in respiratory tract and blood may be related with invasive medical operations.