Study On Pathogenic Bacteria Isolates From Bronchoalveolar Lavage Fluid (BALF) Of Lower Respiratory Tract Infection Patients

Objectives Bronchoalveolar lavage fluid of lower respiratory tract infections were cultivated to isolate fungus and bacteria.To analyze the distribution and antimicrobial resistance pattern of pathogenic bacteria isolates from bronchoalveolar lavage fluid(BALF)of our hospital.And to compare the distribution of pathogenic bacteria and fungus in different crowd. such as structural lung disease or not、Community-acquired infection or not、 endocrine physiology or not、the aged or not. All are to guiding the rational use in clinical settings.Methods Collected clinical isolates of bacteria from bronchoalveolar lavage fluid samples of lower respiratory tract infections infections patients since January 2013 to January 2015, to discuss the result.Results 287 positive pathogenic strains were separated from 255 persistent broncho-pulmonary infections patients, Gram-negative organisms and Gram-positive organisms and fungi saccounting for an average of 70.7% and 26.5% and 2.8%of the total strains respectively.the Klebsiella pneumoniae, Pseudomonas aeruginosa, E.coli and Acinetobacter baumannii were dominant in Gram-negative organisms,while Staphylococcus aureus were the dominant specie.candida albicans were the only specie of fungi.Regard to the drug resistance,Acinetobacter baumannii showed higher drug resistance to the commonly used antibiotics especially for imipenem and meropenem, which were most highly susceptible to Minocycline and Amikacin. no strains were found resistant to vancomycin.structural lung disease and Nosocomial Infection and endocrine physiology and underlying disease and the aged have the higher positive rate. from which More opportunistic pathogen and Staphylococcus aureus were separated.Conclusion The gram-negative bacteria infections account for the majority isolates from BALF of lower respiratory tract infections. Situation of antibiotic resistance was rigorous.Different crowds have Different pathogenic bacterias.Based on the local distribution and drug resistance of pathogenic bacteria, clinicians can choose empiric antibiotic therapy reasonably and adjust the targeted medications in time.