The Comparative Study Of IPSS、WPSS And IPSS-R In MDS Prognosis

Objective:To explore the significance among different scoring systems in predicting the prognosis of myelodysplastic syndrome(MDS), to guide the clinical accurate prognosis stratification and personal treatment.Methods:The clinical data of 72 patients with newly diagnosed MDS were retrospectively reviewed, the prognosis was evaluated according to international prostate symptom score(IPSS), World Health Organization classification-based prognostic scoring system(WPSS) and revised international prognostic scoring system(IPSS-R).Results: The difference of median survival time between different groups of prognostic scoring system was statistically significant(Tarone-Ware=9.572-19.834, P<0.05). The survival curve of WPSS had more intersections between each group,IPSS-R prognosis had less intersections. For low risk group, prognostic evaluation of IPSS and WPSS were poor, IPSS-R was the best way to predict the prognosis. Correlation between IPSS and IPSS-R was the strongest(rs=0.765, P<0.05).Conclusions:All the three scoring systems can better predict the prognosis of patients with newly diagnosed MDS, and IPSS-R has more advantage. Integrated used of 3 scoring system in clinical work is more favorable for clinical prognosis evaluation of MDS.