Atorvastatin Joint According To Fold The Mab Lipid-lowering Efficacy Observed In Patients With Coronary Heart Disease(CHD)

Background:Coronary heart disease, serious harm human health and life,Dyslipidemia important risk factors for coronary heart disease(CHD) and independence,Lipid management has a vital status in the treatment of coronary heart disease. The research and clinical guidelines have shown that,reasonable and effective lipid, which can prevent the occurrence of coronary atherosclerosis Relieve and even reverse the development of coronary atherosclerotic plaque.The sound in the guide of theepidemiological data and the latest confirmed that statins in coronary heart disease has an important role in the secondary treatment, that Is the foundation of lipid adjusting treatment of coronary heart disease. However conventional dose of statins alone lipid,With the aim of LDL- C as reference cholesterol ester success rate is very low. Part of patients with cholesterol fat cannot be reduced to guidelines recommending a reasonable reference value range. The side effects of high-dose statins and worrying. According to fold the emergence of the mab for clinical lipid adjusting treatment has brought a new dawn. Both can lower cholesterol fat from endogenous and exogenous double ways. But in clinical applications, Specific tiaozhi curative effect and safety of the application of reasonable and effective dose not specification. This requires medical workers constantly in-depth study, we provide reasonable and effective guide to specification.Objective: Main research to strengthen dose of 40 mg/d with atorvastatin 20 mg of atorvastatin + 10 mg according to fold the mab/d joint tiaozhi curative effect for the treatment of coronary heart disease(CHD) The standard the blood lipid rate of lipid blood lipids Clinical benefit and safety.Method: Select CT coronary angiography prompted the left coronary artery of right coronary artery or left handed for any one or more of the artery stenosis degree from 30% to 70%, no stent placement and can timely follow-up of 100 cases of patients with as required. Were randomly divided into two groups, group A(Joint lipid group,31 cases) application of atorvastatin calcium 20 mg/d + 10 mg/d; group B(improved group, 31 cases) : use atorvastatin calcium 40 mg/d lipid according to fold the mabtiaozhi all selected patients to take the medicine every night after dinner and only once. Rounding out the top record of each patient’s age gender, respectively Height and weight blood pressure, smoking history and other general information, prior to inclusion in 2 weeks and 4 weeks after 8 weeks, 12 weeks and 24 Zhou Qingchen extract fasting venous blood, regular review of all patients with blood lipid changes(total cholesterol TG TC triglyceride and low density lipoprotein cholesterol LDL- C 、HDL –C). And testing in patients with liver kidney creatine kinase, record the presence of myalgia were observed Muscle dissolve adverse reactions such as nausea vomiting and whether malignant arrhythmia Acute myocardial infarction The occurrence of heart failure and other adverse cardiovascular adverse events within the group in different periods and compared between groups.Result:age 、sex 、ratio between two groups(A、B)General data, such as the height and weight of blood pressure smoking rates were no significant statistical difference.A and B two groups in the medication after 2 week TG TC LDL- C values were decreased, and the HDL- C is into a rising trendA and B two groups after TG TC LDL- C value declines to A > B(P < 0.05), HDL- C rise to A > B(P > 0.05).in A and B two groups of LDL- C standard for A > B,(P < 0.05) with statistical significance.5 A.B two groups after no muscle pain Muscle dissolving reaction No malignant arrhythmia Acute myocardial infarction The occurrence of adverse cardiovascular adverse events such as heart failure, B group of nausea 3 patients with vomiting adverseside effects, and group A are nausea 2 patients with vomiting adverse side effects, not statistically significant(P > 0.05)Conclusion:Atorvastatin 20 mg/d + 10 mg/d according to fold the mabtiaozhi on 40 mg/d atorvastatin strengthen lipid in coronary heart disease(CHD) are safe and effective in the clinical tiaozhi, atorvastatin 20 mg/d + 10 mg/d according to fold the mab lipid-lowering has better curative effect in the treatment of coronary heart disease...