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Clinical Study Of Lymph Node Metastasis In Distal Gastric Cancer

Posted on:2017-02-06Degree:MasterType:Thesis
Country:ChinaCandidate:Z J MaoFull Text:PDF
GTID:2284330503967732Subject:General surgery
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Background: Gastric cancer is one of the most common tumor of digestive system malignant tumor and ranked the second among China’s digestive system malignant tumor.lymph node metastasis of gastric is the main cancer transfer way, Japanese scholars define D2 lymph node dissection is the standard surgery for gastric cancer in gastric resection, and European and American scholars think expansion of cleaning lymph node pair has no meaning to extend the survival time and improve the prognosis,which can only be used to evaluate the prognosis. And at the same time that a wide range of cleaning lymph node surgery may affect the patient’s immune function, which increased trauma. Domestic medical researchers based on a large number of clinical cases shows enlarged lymph nodes cleaning in a certain process degree can improve the prognosis in recent research of the year. Therefore, preoperative understanding the characteristics of metastasis of lymph node, for the choice of surgical approach and postoperative detection based on lymph node pathology is the subject of medical researchers,which need to be continued for further study. The distal stomach is the highest gastric cancer rate position, which has similarities and personality in the lymph node metastasis gastric cancer. Through the continuous research of domestic and foreign medicine for lymph node metastasis, the distal gastric cancer lymph node metastasis will be further clarify.Objective: Study the distal gastric cancer lymph node metastasis,and analysis the reasonable selection of distal gastric cancer surgery and providing the relevant information on gastric cancer standardized surgical treatment for basic data. At the same time, providing basis to improve the gastric cancer after pathological staging and postoperative chemotherapy of combined therapy in lymph node formulation of the stage.Methods: Select 163 patients with distal gastric cancer patients as the research object of the Department of general surgery in Shaanxi Province People’s Hospital from January2014 to 2015 December,which 112 cases of male, 51 cases of female, and male to female ratio is 2.19:1. And the maximum age is 84 years old, minimum is 21 years old,mean age is 58.9. According to the 14 th edition of Japanese gastric cancer treatment principles of the statute in 2011, Distal gastric cancer clinical and pathological data distal gastric D2 lymph node dissection scope division,which shows the station I lymph is the1,3,4,5,6 group, the second station lymph node is group 7,8,9 and 10, l1,12 group.Researchers in this study involved in the treatment of specimens and lymph node tissue were dissected. According to the tag group, which retains the image details of specimen.According to the standard of dividing and detection, lymph node were 10 times on the fixed volume,which regulate the 10% pathological examination in the Department of Pathology.Results: Total removal 4619 lymph node and average is 28.34 gold / person, which 114 patients have lymph node metastasis, total rate of lymph node metastasis is 69.94%, early and advanced distal gastric cancer lymph node metastasis rate was 14.81% respectively.80.88%. All 4619 lymph node and metastasis 1546 gold, which is 33.48% of the total lymph node shift. Tumor size and depth of invasion shows the differentiation, and macroscopic type and lymph node metastasis rate and degree are significant correlation(P < 0.001),which distal gastric cancer is the lymph node station and the second station lymph node metastasis is significantly(P < transfer 0.01. All distal gastric lymph node metastasis from high to low order No5, No3, No6, No7, No4, No1, No9, No8, No11,No10, No12. lymph node metastasis and the number of lymph node metastasis were significantly correlated(r=0.889, p<0.001).Conclusion: 1. Distal gastric cancer invasion is the depth of the tumor, and the pathological differentiation has relationship with degree, tumor, and lymph node metastasis rate, and the lymph node metastasis rate and the location of lesions was not significant, and lymph node metastasis degree and the location of lesions is significantly.2.Distal gastric cancer postoperative pathology showed the existence of the 12 a and11,10 group of the lymph nodes is metastasis and distal gastric cancer is meaningful underwent D2 dissection. 3.There is a significant correlation between Distal gastric cancer lymph node metastases and lymph node metastasis degree t.
Keywords/Search Tags:Distal gastric cancer, Lymph node metastasis, D2 Lymph node dissection, Llymph node metastasis
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