Clinical Analysis Of 27 Cases Of Uterine Serous Carcinoma

Objective:The aim of this study was to identify the clinical and pathologic characteristics and the survival of patients with uterine serous carcinoma(USC).Methods:27 patients with USC in Shanxi Cancer Hospital between January 2003 and January 2013 were identified. Retrospective data review was peformed to investigate clinical and pathologic information and the survival of patients.Results:The mean age at the time of diagnosis was 60.7 years old. Most tumors occured in postmenopausal women(88.9%). The rate of misdiagnosis before su rgery was high(61.1%) with a tendency to be misdiagnosed as grade 3 endome trioid carcinoma. Elevated preoperative CA125 for late and CA125 in patients with normal for late compared with patients without statistical significance(P> 0.05). 22.2% of USC patients with no muscular invasion had extrauterine i nvasion.66.7% of USC had deep myometrial invasion,33.3% had cervix invasio n,31.8% had lymph vascular space invasion and 42.1% had lymphnode invasio n. 83.3% of patients showed expression of p53. The average index of the Ki67 in patients with early and late were 60.0% and 46.7% respectively, which sh owed no statistical significance(P > 0.05).The average index of the Ki67 in pat ients in G1, G2, and G3 were 65%, 60% and 51.7% respectively, and compar e three also has no statistical significance. The three-year overall survival rate and five-year overall survival rate were 61.1% and 27.8%. In a single factor a nalysis,pathologic stage(P=0.041) was associated with a poor prognosis.Conclusions:The age of USC patients was older,and most were post-menopause.The rate of misdiagnosis before surgery on USC was high, which combined with immunohistochemical detection can improve the preoperative diagnostic rate. It had a tenency of extrauterine metastasis. The detection of CA125 before surgery may be not meningful to predict extrauterine metastasis. The expression of p53 was its important molecular biolgical feature.Ki67 index may not be the basis of judging the progress of USC.pathologic stage,cervix invasion and lymphnode positivity were associated with a poor prognosis.