Effect Of Aerobic Exercise In Nonalcoholic Fatty Liver Disease Patients: A Meta-analysis

Objective:In recent years, Nonalcoholic fatty liver disease is very common clinically with increasing incidence in digestive system diseases. Nonalcoholic fatty liver disease has become a threat to people’s health hazard. Nonalcoholic fatty liver disease is widely considered to be one of the most common causes of liver disease at present. To investigate whether aerobic exercise can prevent or improve the condition of nonalcoholic fatty liver disease or not, we will search the aerobic exercise researches, evaluate the efficacy of indicators including liver function, blood fat and liver lipid after patients accepting this kind of intervention.Methods: According to the inclusion criteria, search the the Cochrane Library、EMBASE、Web of Science、Chinese Biomedical Database and WANFANG, VIP databases while determine the key words, choose random and controlled trials of aerobic exercise combined with nonalcoholic fatty liver disease. Data extraction of articles and methodology of included research and quality evaluation will be carried out by two authors. Regard Cochrane reviewer handbook as guidelines for the assessment of extracting data, use Rev Man5.2 software for Meta-analysis.Result:This study included 6 researches including 206 participants. The result was that aerobic exercise can improve IHL of NAFLD patients [MD=-3.29,95%CI:-5.53~-1.05,P=0.004]. However, when we analyzed the exercise alone vs. control(without diet intervention or other interventions in both groups), there was no significant efficacy on liver function, blood fat and body mass index, respectively, [ALT, SMD=0.12,95%CI:-0.23~0.48,P=0.49; AST, SMD=0.27,95%CI:-0.11~0.65,P=0.16; TG, SMD=-0.04,95%CI:-0.40~0.32,P=0.93; TC:SMD=-0.33,95%CI:-0.68~0.02,P=0.06; HDL, SMD=0.02,95%CI:-0.31~0.35,P=0.90; LDL, SMD=-0.07,95%CI:-0.42~0.28,P=0.68; BMI, MD=0.33,95%CI:-2.50~3.15,P=0.82].Conclusion:A erobic exercise can improve the condition of nonalcoholic fatty liver disease on IHL instead of liver functions and blood fat. The structure of aerobic exercise and how to use the interventions of lifestyle are worthy of further exploration.