Antibody Detection In Mice After Immunized With Polyvalent Vaccine

In the world, there are more and more vaccines absorbed into the Expanded Program on Immunization. In order to reduce the immune burden and cross-infection,World Health Organization suggested to develop combination vaccines. These combination vaccines are intended to reduce discomfort by decreasing the number of injections, decrease the cost of vaccine delivery, and simplify storage. In addition to this, it is expected that combination vaccines will increase compliance with vaccination and ultimately improve vaccine coverage. Combination vaccines were the vaccine reseach development.This paper aims to the company’s production of the DTaP vaccine, the Men A C vaccine, the Hib vaccine with fixed concentration ratio of pairwise combined, After three weeks of basic immunization, the mice were immunized with the combined vac cine and the single component vaccine. The ELISA technique was used to detect the antibody IgG and IgM titer in mice.By comparing the levels and types of antibodies in different periods. The results that the combined vaccine, each component between ant igen compatibility to induce high antibody titers, and antibody trend compared to one component vaccine is more stable, with good immunogenicity and persistence.